The Ministry of Foreign Affairs has confirmed that two New Zealanders have died in a plane crash in the Philippines. 

All nine people on board a small Beechcraft King Air 350 medical evacuation plane were killed when the aircraft crashed into a resort area near Calamba City and exploded in flames, officials said.

A small plane crashed into a resort area south of the Philippine capital and exploded in flames.

It's understood that a New Zealand man was the patient on board, travelling with his wife, along with a pilot, First Officer, one doctor, two nurses, and two other people.

The light plane crashed into a resort compound in Pansol village in Laguna province near the foothills of Mount Makiling.

Two people on the ground were injured and brought to a hospital.

Rescuers look at the site where a plane crashed in Laguna, south of Manila.

Eric Apolonio, a spokesman of the Civil Aviation Authority of the Philippines, said the light plane was on a medical evacuation flight from southern Dipolog city in Zamboanga del Norte province and disappeared from radar for unknown reasons as it flew over Laguna, about 60 kilometres south of the capital.

The plane was supposed to land in Manila.

Videos posted online by witnesses showed flames and black smoke billowing from the private resort compound in Pansol, a district popular for its hot springs and swimming pools.

Firefighters and an ambulance can be seen near the scene of the crash as local officials asked villagers to step back to a safe distance.

The crash happened during the monsoon season, when fewer people visit Pansol's resorts compared to the hot summer months that ended in June.